Perricone C, Alessandri C, Valesini G
Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155, Rome, Italy.
Reumatismo. 2011;63(2):63-6. doi: 10.4081/reumatismo.2011.63.
Recently, Shoenfeld and Agmon-Levin described a potential new syndrome, namely ASIA - autoimmune/inflammatory syndrome induced by adjuvants, that comprises four medical conditions: siliconosis, the Gulf war syndrome, the macrophagic myofasciitis syndrome and post-vaccination phenomena, characterized by hyperactive immune responses accompanied by a similar complex of signs and symptoms. Most relevantly, these conditions share a linkage represented by adjuvants. This common soil may possibly induce autoimmune or auto-inflammatory diseases in humans as it was demonstrated in different animal models. Reconsidering under a unified umbrella this apparently detached condition is not only intriguing, but also provocative, and may help in unraveling novel pathogenetic mechanisms, preventive measures, and therapeutic targets.
最近，绍恩菲尔德和阿格蒙-莱文描述了一种潜在的新综合征，即ASIA——由佐剂诱发的自身免疫性/炎症性综合征，它包含四种病症：矽肺、海湾战争综合征、巨噬细胞性肌筋膜炎综合征和疫苗接种后现象，其特征为免疫反应亢进并伴有相似的一系列体征和症状。最相关的是，这些病症存在由佐剂所代表的一种联系。这种共同根源可能在人类中诱发自身免疫性或自身炎症性疾病，正如在不同动物模型中所证实的那样。在一个统一框架下重新审视这种明显不相关的病症不仅有趣，而且具有启发性，可能有助于揭示新的发病机制、预防措施和治疗靶点。
