Coppola Maurizio, Mondola Raffaella
a Medical Manager, Department of Addiction , ASL CN2 , Alba , Italy.
b Medical Manager, Department of Mental Health , ASL CN1 , Saluzzo , Italy.
J Psychoactive Drugs. 2017 Jul-Aug;49(3):262-265. doi: 10.1080/02791072.2017.1316431. Epub 2017 Apr 25.
Synthetic cannabinoid receptor agonists are a heterogeneous group of psychotropic drugs functionally related to Δ9-tetrahydrocannabinol. These substances, marketed as cannabis substitutes, have been associated with numerous cases of severe intoxication and death across the world. In our article, we describe a case of hallucinogen persisting perception disorder developing in a natural cannabis user after consumption of JWH-122, a naphthoylindole largely used since 2010. Clinical symptomatology persisted for about four years and was alleviated through treatment with clonazepam. Considering that natural cannabis consumption can induce the development of a hallucinogen persisting perception disorder, it is not excluded that, in our patient, symptoms lasted a long time due to cannabis consumption. This article describes the clinical evolution from onset to resolution of all symptoms.
合成大麻素受体激动剂是一类与Δ9-四氢大麻酚功能相关的精神药物。这些作为大麻替代品销售的物质，在全球范围内已与众多严重中毒和死亡案例相关联。在我们的文章中，我们描述了一名天然大麻使用者在服用JWH-122（一种自2010年以来大量使用的萘酰吲哚）后发生致幻剂持续性感知障碍的病例。临床症状持续了约四年，并通过氯硝西泮治疗得到缓解。考虑到天然大麻消费可诱发致幻剂持续性感知障碍的发生，不排除在我们的患者中，症状因大麻消费而持续了很长时间。本文描述了所有症状从发作到缓解的临床演变过程。
