Leistenschneider Georg, Majić Tomislav, Reiche Simon, Riemer Thomas G
Department of Psychology, Humboldt-Universität zu Berlin, 12489, Berlin, Germany.
Campus Charité Mitte, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Psychiatric University Clinic at Hospital St. Hedwig, 10115, Berlin, Germany.
Sci Rep. 2024 Dec 31;14(1):32159. doi: 10.1038/s41598-024-82216-x.
Classic psychedelics like LSD and psilocybin are showing promising effects in treating certain psychiatric disorders. Despite their low toxicity and lack of an addictive potential, in some individuals, psychedelics can be associated with persisting psychological harms. Hallucinogen Persisting Perception Disorder (HPPD) is one of those complications, a rare disorder characterized by enduring perceptual symptoms without impaired reality control. While the phenomenological aspects of HPPD have been characterized, the neuropsychological consequences have remained understudied. This study probes the neuropsychological profiles of eight individuals with HPPD, utilizing a comprehensive test battery. Performance is benchmarked against normative data and compared with two control groups, each comprising eight matched subjects-with and without prior psychedelic use. The assessment of individual performances revealed below average results in tests of visual memory and executive function in some subjects. No significant differences were observed in alpha-adjusted comparisons with controls, whereas unadjusted analyses were suggestive of impaired executive functions among HPPD patients. Together, these preliminary results underline the need for further focused research into the neuropsychological dimensions of HPPD.
像麦角酸二乙酰胺（LSD）和裸盖菇素这样的经典致幻剂在治疗某些精神疾病方面显示出了有前景的效果。尽管它们毒性低且没有成瘾潜力，但在一些个体中，致幻剂可能会带来持续的心理伤害。致幻剂持续性感知障碍（HPPD）就是其中一种并发症，这是一种罕见的疾病，其特征是存在持久的感知症状且现实检验能力未受损。虽然HPPD的现象学方面已经得到了描述，但其神经心理学后果仍未得到充分研究。本研究使用一套综合测试组对八名患有HPPD的个体的神经心理学特征进行了探究。将表现与标准数据进行基准对比，并与两个对照组进行比较，每个对照组都由八名匹配的受试者组成——一组有过致幻剂使用经历，另一组没有。对个体表现的评估显示，一些受试者在视觉记忆和执行功能测试中的结果低于平均水平。在与对照组进行α调整后的比较中未观察到显著差异，而未经调整的分析表明HPPD患者存在执行功能受损的情况。总之，这些初步结果强调了有必要对HPPD的神经心理学维度进行进一步的针对性研究。
