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丁丙诺啡治疗患者中使用苯巴比妥逐渐减量治疗生理性苯乙哌啶依赖的病例报告

Case Report of Physiologic Phenibut Dependence Treated With a Phenobarbital Taper in a Patient Being Treated With Buprenorphine.

作者信息

Brunner Emily, Levy Robert

机构信息

Healtheast, St. Paul (EB); and Family Medicine and Community Health, University of Minnesota, Minneapolis, MN (RL).

出版信息

J Addict Med. 2017 May/Jun;11(3):239-240. doi: 10.1097/ADM.0000000000000303.

DOI:10.1097/ADM.0000000000000303
PMID:28441273
Abstract

: This case report describes the development of dependence to phenibut, a gamma-aminobutyric acid-receptor type B agonist, in a patient concurrently being treated with buprenorphine. The patient experienced withdrawal symptoms which were successfully treated with a phenobarbital taper based on a protocol to treat sedative use disorder. This case report provided an example of the development of a phenibut use disorder and also brought up a public health question of whether phenibut should therefore be officially classified and monitored.

摘要

本病例报告描述了一名正在接受丁丙诺啡治疗的患者对γ-氨基丁酸B型受体激动剂苯乙胺酪酸产生依赖的情况。患者出现了戒断症状,根据治疗镇静剂使用障碍的方案,通过逐渐减少苯巴比妥剂量成功进行了治疗。本病例报告提供了一个苯乙胺酪酸使用障碍发展的实例,同时也提出了一个公共卫生问题,即苯乙胺酪酸是否因此应被正式分类和监测。

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