Al Diffalha Sameer, Al Aukla Nidal, Hasan Saleh, Dickinson Shohreh, Khalil Farah
Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL.
Cancer Control. 2017 Apr;24(2):202-206. doi: 10.1177/107327481702400214.
Nuclear protein of the testis (NUT) midline carcinoma can present in the head, neck, and mediastinum. In general, it presents in young adult men and has a poor prognosis. We report on a case of NUT midline carcinoma of the mediastinum in a man 27 years of age without any prior malignancy. Due to the location of the tumor, mediastinal lymphoma and germ cell tumor were initially considered; however, immunohistochemistry was performed using NUT antibody that revealed it to be NUT midline carcinoma. Although guidelines exist for squamous cell carcinoma of the head, neck, and mediastinum, no such specific guidelines are available for NUT midline carcinoma, which looks morphologically similar to squamous cell carcinoma but behaves more aggressively and carries a poor prognosis.
睾丸核蛋白（NUT）中线癌可出现在头颈部和纵隔。一般来说，它好发于年轻成年男性，预后较差。我们报告一例27岁男性的纵隔NUT中线癌，该患者既往无任何恶性肿瘤病史。由于肿瘤的位置，最初考虑为纵隔淋巴瘤和生殖细胞肿瘤；然而，使用NUT抗体进行免疫组化检查后显示为NUT中线癌。虽然对于头颈部和纵隔的鳞状细胞癌有相关指南，但对于NUT中线癌尚无此类具体指南，NUT中线癌在形态学上与鳞状细胞癌相似，但行为更具侵袭性，预后较差。
