Still Emma R, Yuneva Mariia O
Oncogenes and Tumour Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Br J Cancer. 2017 May 23;116(11):1375-1381. doi: 10.1038/bjc.2017.113. Epub 2017 Apr 25.
Altered cell metabolism enables tumours to sustain their increased energetic and biosynthetic needs. Although tumour metabolism has long been considered a promising discipline in the development of cancer therapeutics, the majority of work has focused on changes in glucose metabolism. However, the complexity of cellular metabolism means that very rarely is an individual metabolite required for a single purpose, and thus understanding the overall metabolic requirements of tumours is vital. Over the past 30 years, increasing evidence has shown that many tumours require glutamine as well as glucose for their proliferation and survival. In this minireview, we explore the complexity of glutamine metabolism in tumour cells, discussing how the overall context of the tumour dictates the requirement for glutamine and how this can affect the design of effective therapeutic strategies.
细胞代谢的改变使肿瘤能够维持其增加的能量和生物合成需求。尽管长期以来肿瘤代谢一直被认为是癌症治疗发展中一个有前景的学科，但大多数工作都集中在葡萄糖代谢的变化上。然而，细胞代谢的复杂性意味着很少有单个代谢物仅用于单一目的，因此了解肿瘤的整体代谢需求至关重要。在过去30年中，越来越多的证据表明，许多肿瘤的增殖和存活需要谷氨酰胺以及葡萄糖。在这篇小型综述中，我们探讨了肿瘤细胞中谷氨酰胺代谢的复杂性，讨论了肿瘤的整体环境如何决定对谷氨酰胺的需求以及这如何影响有效治疗策略的设计。
