Cha Byung Hyo, Lee Ban Seok, Lee Sang Hyub, Kang Seung Joo, Park Min Jung
Department of Gastroenterology, Division of Medicine, Sheikh Khalifa Specialty Hospital, Truck Road, Ras Al Khaimah, United Arab Emirates. Email:
Asian Pac J Cancer Prev. 2017 Mar 1;18(3):715-719. doi: 10.22034/APJCP.2017.18.3.715.
Background: Gallbladder stone (GBS) is a common gastrointestinal disease that can progress to severe cholecystitis and is a strong risk factor for gallbladder cancer (GBC). The present study was conducted to evaluate region-specific causes of GBS which was proved as major risk factor for GBC in Jeju Island, Korea. Methods: Age and sex match case-control study was performed among 171 pairs of case and controls. The cases were patients who were diagnosed with GBS, had definite clinical symptoms, and underwent a cholecystectomy in Cheju Halla General Hospital, Jeju, Korea during 2010-2014. The control group included 1:1 age and sex-matched participants without GBS at the Health Promotion Center in the same institute during the same period. We compared the histories of previous chronic diseases (hypertension, diabetes, hyperlipidaemia, vascular occlusive diseases, or parity), alcohol consumption (standard drinks/week [SDW]), smoking habits, body mass index (BMI), and presence of concomitant polypoid lesions of the gallbladder. Results: A dose-dependent positive relationship existed between BMI and the risk of GBS: BMI 23–27.4 kg/m2, OR=2.5, , p=0.24; 27.5–29.9 kg/m2, OR=8.9, p=0.002; ≥30 kg/m2, OR=7.2, p=0.004. A negative correlation existed between alcohol consumption and the risk of GBS: Standard drinks per week (SDW), OR=0.24, p=0.002; 15–29.9 SDW, OR=0.26, p=0.022; ≥30 SDW, OR=0.2, 95% p=0.005. Conclusion: The present results suggest that a higher BMI and less alcohol consumption are associated with a risk of symptomatic GBS.
胆囊结石（GBS）是一种常见的胃肠道疾病，可发展为严重胆囊炎，是胆囊癌（GBC）的重要危险因素。本研究旨在评估GBS的地区特异性病因，GBS被证明是韩国济州岛GBC的主要危险因素。方法：在171对病例和对照中进行年龄和性别匹配的病例对照研究。病例为2010 - 2014年期间在韩国济州济洲汉拿综合医院被诊断为GBS、有明确临床症状并接受胆囊切除术的患者。对照组包括同期在同一机构健康促进中心年龄和性别1:1匹配的无GBS参与者。我们比较了既往慢性病（高血压、糖尿病、高脂血症、血管闭塞性疾病或生育史）、饮酒量（标准饮酒量/周[SDW]）、吸烟习惯、体重指数（BMI）以及胆囊息肉样病变的存在情况。结果：BMI与GBS风险之间存在剂量依赖性正相关：BMI 23 - 27.4 kg/m²，OR = 2.5，p = 0.24；27.5 - 29.9 kg/m²，OR = 8.9，p = 0.002；≥30 kg/m²，OR = 7.2，p = 0.004。饮酒量与GBS风险之间存在负相关：每周标准饮酒量（SDW），OR = 0.24，p = 0.002；15 - 29.9 SDW，OR = 0.26，p = 0.022；≥30 SDW，OR = 0.2，95% p = 0.005。结论：目前的结果表明，较高的BMI和较少的饮酒量与有症状GBS的风险相关。
