Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
VTT Technical Research Centre of Finland Ltd., Espoo, Finland.
Schizophr Res. 2018 Feb;192:398-403. doi: 10.1016/j.schres.2017.04.017. Epub 2017 Apr 22.
The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.
肠道微生物群对中枢神经系统的影响及其在精神障碍中的可能作用，越来越受到关注。在这里，我们研究了 28 名首发精神病患者（FEP）和 16 名健康匹配对照者粪便微生物群之间的差异，并探讨了这些差异是否与治疗 12 个月后的反应相关。FEP 患者的乳杆菌组细菌数量增加，且与不同症状领域的严重程度显著相关。FEP 患者中具有最强微生物群差异的亚组在治疗 12 个月后反应也较差。本研究结果支持微生物群改变与精神病的发生有关，并可能为探索其调节对治疗反应和缓解的益处提供依据。
