Zhang Senfeng, Lei Fang, Zhao Fusheng, Yan Xiang, Wang Wen, Zheng Yu
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
Respir Physiol Neurobiol. 2017 Sep;243:1-6. doi: 10.1016/j.resp.2017.04.009. Epub 2017 Apr 23.
The present study was designed to investigate whether HS could improve the respiratory responses to hypercapnia blunted by prenatal CSE in neonatal rats in vivo. Respiratory activities were recorded with head-out body plethysmography. The results showed that during baseline, respiratory frequency (F), tidal volume (V) and minute ventilation (V) were similar among tested groups; frequency of spontaneous apnea (F), not post-sigh apnea (F), was significantly elevated by prenatal CSE. During hypercapnia, the increases in F and V were significantly reduced, but V was not markedly different, in CSE group; both F and F were decreased, although F remained higher in CSE group. All the aforementioned effects induced by CSE on respiratory activities were relieved by NaHS (donor of HS, 56μmol/kg by intraperitoneal injection). These data indicate that HS could ameliorate the disruption of respiratory responses to hypercapnia induced by prenatal CSE in neonatal rats.
