Wang Ji, Lei Fang, Fu Ya-Ting, Zheng Yu
Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, PR China; Department of Anesthesiology, North Sichuan Medical College, Nanchong, PR China.
Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, PR China.
Respir Physiol Neurobiol. 2021 Feb;284:103582. doi: 10.1016/j.resp.2020.103582. Epub 2020 Nov 13.
Prenatal cigarette smoke (CS) exposure causes numerous respiratory health problems in infants. This study aimed to investigate the effect of prenatal CS exposure on sevoflurane-induced respiratory suppression in neonatal rats and the protective role of HS. We found that at baseline, minute ventilation (V'), respiratory frequency (f), and tidal volume (V) were similar among tested groups, whereas sigh frequency (f) was lower in CS group than in the Control group. During 3 % sevoflurane anesthesia, V' was decreased, f was slowed, V was increased, and f was reduced in all groups; however, the decline in f and increase in V was greater in CS group than in the Control group. During the recovery, f remained lower in CS group. The above changes of respiratory response caused by prenatal CS exposure were alleviated by NaHS pretreatment (a donor of HS, 56 μmol/kg/d, intraperitoneal injection). These results indicated that prenatal CS exposure alters the breathing into a much slower and deeper manner in neonatal rats during sevoflurane anesthesia, and HS mitigates this respiratory change.
产前接触香烟烟雾（CS）会导致婴儿出现众多呼吸道健康问题。本研究旨在探讨产前接触CS对新生大鼠七氟醚诱导的呼吸抑制的影响以及硫化氢（HS）的保护作用。我们发现，在基线时，各测试组之间的分钟通气量（V'）、呼吸频率（f）和潮气量（V）相似，而CS组的叹息频率（f）低于对照组。在3%七氟醚麻醉期间，所有组的V'均降低，f减慢，V增加，f降低；然而，CS组的f下降和V增加幅度大于对照组。在恢复过程中，CS组的f仍然较低。产前接触CS引起的上述呼吸反应变化通过NaHS预处理（HS供体，56 μmol/kg/d，腹腔注射）得到缓解。这些结果表明，产前接触CS会使新生大鼠在七氟醚麻醉期间的呼吸方式变得更慢更深，而HS可减轻这种呼吸变化。
