Read Ethan, Zhu Jiechun, Yang Guangdong
Department of Chemistry and Biochemistry, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Cardiovascular and Metabolic Research Unit, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Antioxidants (Basel). 2021 Jan 3;10(1):49. doi: 10.3390/antiox10010049.
The role of endogenous hydrogen sulfide (HS) as an antioxidant regulator has sparked interest in its function within inflammatory diseases. Cigarette and alcohol use are major causes of premature death, resulting from chronic oxidative stress and subsequent tissue damage. The activation of the Nrf2 antioxidant response by HS suggests that this novel gasotransmitter may function to prevent or potentially reverse disease progression caused by cigarette smoking or alcohol use. The purpose of this study is to review the interrelationship between HS signaling and cigarette smoking or alcohol drinking. Based on the databases of cellular, animal, and clinical studies from Pubmed using the keywords of HS, smoking, and/or alcohol, this review article provides a comprehensive insight into disrupted HS signaling by alcohol drinking and cigarette smoking-caused disorders. Major signaling and metabolic pathways involved in HS-derived antioxidant and anti-inflammatory responses are further reviewed. HS supplementation may prove to be an invaluable asset in treating or preventing diseases in those suffering from cigarette or alcohol addiction.
内源性硫化氢（HS）作为一种抗氧化调节剂的作用，引发了人们对其在炎症性疾病中功能的兴趣。吸烟和饮酒是过早死亡的主要原因，这是由慢性氧化应激及随后的组织损伤导致的。HS对Nrf2抗氧化反应的激活表明，这种新型气体信号分子可能起到预防或潜在逆转吸烟或饮酒引起的疾病进展的作用。本研究的目的是综述HS信号与吸烟或饮酒之间的相互关系。基于来自PubMed的细胞、动物和临床研究数据库，使用HS、吸烟和/或酒精等关键词，这篇综述文章全面深入地探讨了饮酒和吸烟导致的疾病对HS信号的破坏。进一步综述了HS衍生的抗氧化和抗炎反应所涉及的主要信号和代谢途径。补充HS可能被证明是治疗或预防吸烟或酒精成瘾者疾病的一项宝贵资产。
