Combalia Andrea, Baliu-Piqué Carola, Fortea Adriana, Ferrando Juan
Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain.
Department of Psichyatry, Hospital Clinic de Barcelona, Barcelona, Spain.
Int J Trichology. 2016 Oct-Dec;8(4):171-172. doi: 10.4103/0974-7753.203171.
We present a case of a 17-year-old girl admitted to the Psychiatric Department recovering from a suicide attempt with colchicine. One week after poisoning, a sudden onset of hair loss was observed. Positive hair pull test and trichoscopy demonstrated the presence of anagen hairs with pigmented long roots covered by the root sheaths. Colchicine poisoning is an uncommon, but potentially life-threatening toxicologic emergency. An overdose of colchicine inhibits cell division, and thus the most affected organs are those which have a high rate of cell turnover. Hair loss resulting from colchicine poisoning presents as anagen effluvium, as it occurs with an exposure to toxic chemicals. Pharmacotherapy or specific treatment is not usually required, since the follicle resumes its normal activity after withdrawal of the antimitotic factors.
我们报告一例17岁女孩，因服用秋水仙碱自杀未遂后入住精神科。中毒一周后，突然出现脱发。毛发牵拉试验阳性及毛发镜检查显示存在生长期毛发，其色素沉着的长根被根鞘覆盖。秋水仙碱中毒是一种罕见但可能危及生命的毒理学急症。秋水仙碱过量会抑制细胞分裂，因此受影响最严重的器官是那些细胞更新率高的器官。秋水仙碱中毒导致的脱发表现为生长期脱发，因为它是在接触有毒化学物质后发生的。通常不需要药物治疗或特殊治疗，因为在抗有丝分裂因子撤除后毛囊会恢复正常活动。
