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一类新型的带有水溶性CAP配体的半三明治型钌（II）芳烃配合物作为体外抗癌剂

New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent.

作者信息

Guerriero Antonella, Oberhauser Werner, Riedel Tina, Peruzzini Maurizio, Dyson Paul J, Gonsalvi Luca

机构信息

Istituto di Chimica dei Composti Organometallici, Consiglio Nazionale delle Ricerche , Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy.

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale Lausanne , CH-1015 Lausanne, Switzerland.

出版信息

Inorg Chem. 2017 May 15;56(10):5514-5518. doi: 10.1021/acs.inorgchem.7b00915. Epub 2017 Apr 26.

DOI:10.1021/acs.inorgchem.7b00915
PMID:28443659
Abstract

Ruthenium(II) arene complexes of 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) were obtained. Cytotoxicity studies against cancer cell lines reveal higher activity than the corresponding PTA analogues and, in comparison to the effects on noncancerous cells, the complexes are endowed with a reasonable degree of cancer cell selectivity.

摘要

获得了1,4,7-三氮杂-9-磷杂三环[5.3.2.1]十三烷（CAP）的钌（II）芳烃配合物。针对癌细胞系的细胞毒性研究表明，其活性高于相应的PTA类似物，并且与对非癌细胞的影响相比，这些配合物具有合理程度的癌细胞选择性。

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