含有N^N螯合亚氨基吡啶配体的半夹心钌（II）配合物，对癌细胞具有选择性毒性。
Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.
作者信息
Tian Meng, Li Juanjuan, Zhang Shumiao, Guo Lihua, He Xiangdong, Kong Deliang, Zhang Hairong, Liu Zhe
机构信息
Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
出版信息
Chem Commun (Camb). 2017 Nov 28;53(95):12810-12813. doi: 10.1039/c7cc08270c.
Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η-bz)Ru(N^N)Cl]PF to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.
化疗因其对癌细胞的选择性比对正常细胞差而受到限制。在此，我们设计了半夹心钌亚氨基吡啶配合物[(η-bz)Ru(N^N)Cl]PF，以实现对癌细胞的选择性细胞毒性。这种钌配合物具有独特的特性，在新型抗癌药物的设计中值得进一步探索。
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