Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
Dalton Trans. 2019 Apr 9;48(15):4788-4793. doi: 10.1039/c9dt00999j.
Most half-sandwich metal anticancer complexes are non-fluorescent, which results in an uncertain mechanism of action (MoA). We designed and synthesized eight fluorescent half-sandwich iridium (Ir) and ruthenium (Ru) complexes by introducing rhodamine derivatives into the N^N-chelating ligand. These complexes have features of bio-imaging and anticancer agents and may merit future development as novel anticancer agents.
大多数半三明治金属抗癌配合物是非荧光的，这导致作用机制（MoA）不确定。我们通过将罗丹明衍生物引入 N^N 螯合配体来设计和合成了八个荧光半三明治铱（Ir）和钌（Ru）配合物。这些配合物具有生物成像和抗癌剂的特性，可能有希望作为新型抗癌剂进一步开发。
