Lovreglio Piero, De Filippis Giovanni, Tamborrino Brizio, Drago Ignazio, Rotondi Rossana, Gallone Annamaria, Paganelli Matteo, Apostoli Pietro, Soleo Leonardo
a Interdisciplinary Department of Medicine, Section of Occupational Medicine "E.C. Vigliani" , Università di Bari Aldo Moro , Bari , Italy.
b Department of Prevention , SPESAL ASL Lecce , Lecce , Italy.
Arch Environ Occup Health. 2018;73(5):270-277. doi: 10.1080/19338244.2017.1322934. Epub 2017 May 16.
The contribution of biological and environmental monitoring to the risk assessment of occupational exposure to lead (Pb), arsenic (As), and antimony (Sb) was studied in 18 workers at a birdshot factory (Exposed) and in 18 control workers (Controls) by the determination of both airborne Pb (PbA) and airborne As (AsA) only in the exposed workers and blood Pb (PbB), erythrocytic zinc protoporphyrin (ZPP), urinary Sb (SbU), and the urinary As species in exposed workers and controls. PbA (12-42 μg/m) and AsA (1-4 μg/m) were strongly correlated (r = .95). PbB, ZPP, and the sum of As+As+MMA were significantly higher in the exposed workers. As was higher than the limit of detection in 14 exposed workers and 1 control, As only in 1 exposed worker, SbU in all the exposed workers and in 4 controls. Monitoring for more metallic elements reveals a wider spectrum of exposures than can be achieved by lead surveillance alone and is preferable for characterizing occupational risk wherever possible.
通过仅在暴露工人中测定空气中铅（PbA）和空气中砷（AsA），以及在暴露工人和对照工人中测定血铅（PbB）、红细胞锌原卟啉（ZPP）、尿锑（SbU）和尿砷形态，研究了生物监测和环境监测对职业性铅（Pb）、砷（As）和锑（Sb）暴露风险评估的贡献。研究对象为一家鸟枪弹工厂的18名工人（暴露组）和18名对照工人（对照组）。PbA（12 - 42μg/m³）与AsA（1 - 4μg/m³）高度相关（r = 0.95）。暴露工人的PbB、ZPP以及As+As+MMA的总和显著更高。14名暴露工人和1名对照中的砷高于检测限，仅1名暴露工人中的砷单独高于检测限，所有暴露工人和4名对照中的SbU高于检测限。对更多金属元素进行监测可揭示比仅通过铅监测更广泛的暴露谱，并且在可能的情况下，对于表征职业风险更可取。
