Li Hong-He, Li Xiao-Xiao, Zhao Zhi-Gang, Yuan Xiao, Sun Chen-Yang
College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, People's Republic of China.
Org Biomol Chem. 2017 May 10;15(18):4005-4013. doi: 10.1039/c7ob00882a.
A strategy for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides is presented. This reaction was conducted under very mild conditions and gave up to 99% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.
本文提出了一种通过烯丙酰胺与N-卤代酰亚胺的区域选择性1,2-加成反应合成2-卤代烯丙基缩醛胺衍生物的策略。该反应在非常温和的条件下进行，产率高达99%。此外，所得到的卤化物可通过钯催化的偶联反应实现官能团多样化，其可作为合成有价值化合物的潜在中间体。
