State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P.R. China.
Org Lett. 2014 Apr 18;16(8):2236-9. doi: 10.1021/ol500741a. Epub 2014 Apr 4.
A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in a short time and avoid the use of expensive and toxic metal catalysts. Moreover, the resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds.
本文提出了一种通过 1-（2-乙炔基苯基）-4-羟基丁-2-炔-1-酮衍生物的串联碘环化反应合成螺缩酮化合物的策略。该反应可以在非常温和的条件下短时间内进行，并且避免使用昂贵和有毒的金属催化剂。此外，生成的卤化物可以通过随后的钯催化偶联反应进一步利用，这些反应作为构建其他有价值化合物的重要中间体。
