[3,3]-Sigmatropic rearrangement of allenic alcohols: stereoselective synthesis of 1,3-diene-2-ol sulfonates.
作者信息
Zhao Yuyang, Wang Yurong, Gu Zhanshou, Wang Zhiming
机构信息
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311400, P. R. China.
出版信息
Org Biomol Chem. 2017 May 10;15(18):4014-4021. doi: 10.1039/c7ob00578d.
PMID:28443891
Abstract
An efficient synthetic pathway to 1,3-diene-2-ol sulfonates involving the [3,3]-sigmatropic rearrangement of allenic alcohols with sulfonic acids under mild reaction conditions is described. These products can easily undergo reduction or transition-metal catalyzed cross-coupling reactions to yield a series of stereodefined multisubstituted 1,3-dienes.
摘要
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