Zhao Yuyang, Wang Yurong, Gu Zhanshou, Wang Zhiming
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311400, P. R. China.
Org Biomol Chem. 2017 May 10;15(18):4014-4021. doi: 10.1039/c7ob00578d.
An efficient synthetic pathway to 1,3-diene-2-ol sulfonates involving the [3,3]-sigmatropic rearrangement of allenic alcohols with sulfonic acids under mild reaction conditions is described. These products can easily undergo reduction or transition-metal catalyzed cross-coupling reactions to yield a series of stereodefined multisubstituted 1,3-dienes.
