Neta Adélia da Costa Pereira de Arruda, Farias José Cazuza de, Martins Pamela Rodrigues, Ferreira Flávia Emília Leite de Lima
Universidade Federal da Paraíba, João Pessoa, Brasil.
Cad Saude Publica. 2017 Apr 20;33(3):e00029316. doi: 10.1590/0102-311X00029316.
The objective was to evaluate the conicity index (C Index) as a predictor of changes in the lipid profile of adolescents and to establish its cutoff points. This was a cross-sectional study in 774 adolescents of both sexes (55% girls), 10 to 14 years of age. C Index was calculated according to the formula proposed by Valdez, considering body mass, height, and waist circumference (WC). Changes in the adolescents' lipid profile were defined according to one of the following conditions: elevated levels of total cholesterol, low-density lipoprotein (LDL), and triglycerides and low levels of high-density lipoprotein (HDL). The predictive power of the conicity index for altered lipid profile and its cutoff points were determined by Receiver Operating Characteristic (ROC) curves. The C Index was a good predictor of lipid alterations in adolescents, emphasizing triglycerides in boys 10 to 11 years of age (ROC = 0.67; 95%CI: 0.50-0.85) and 12 to 14 (ROC = 0.69; 95%CI: 0.59-0.80), and in girls 10 to 11 years (ROC = 0.65; 95%CI: 0.50-0.79); and LDL in girls 10 to 11 years (ROC = 0.70; 95%CI: 0.59-0.80) and boys (ROC = 0.65; 95%CI: 0.55-0.75) and girls (ROC = 0.62; 95%CI: 0.50-0.75) 12 to 14 years. The cutoff points for the C Index varied from 1.12 to 1.16 between boys and girls. The C Index can be used to predict lipid alterations, and its cutoff points can be used to screen adolescents for risk of alterations in lipid profile.
目的是评估锥度指数（C指数）作为青少年血脂谱变化预测指标的价值，并确定其切点。这是一项横断面研究，纳入了774名10至14岁的青少年（55%为女孩）。根据瓦尔迪兹提出的公式，考虑体重、身高和腰围（WC）来计算C指数。青少年血脂谱的变化根据以下条件之一定义：总胆固醇、低密度脂蛋白（LDL）和甘油三酯水平升高，以及高密度脂蛋白（HDL）水平降低。通过受试者工作特征（ROC）曲线确定锥度指数对血脂谱改变的预测能力及其切点。C指数是青少年血脂改变的良好预测指标，在10至11岁男孩中对甘油三酯的预测效果显著（ROC = 0.67；95%CI：0.50 - 0.85），在12至14岁男孩中也有较好预测效果（ROC = 0.69；95%CI：0.59 - 0.80），在10至11岁女孩中对甘油三酯的预测效果为（ROC = 0.65；95%CI：0.50 - 0.79）；在10至11岁女孩中对LDL的预测效果为（ROC = 0.70；95%CI：0.59 - 0.80），在12至14岁男孩中对LDL的预测效果为（ROC = 0.65；95%CI：0.55 - 0.75），在12至14岁女孩中对LDL的预测效果为（ROC = 0.62；95%CI：0.50 - 0.75）。男孩和女孩的C指数切点在1.12至1.16之间。C指数可用于预测血脂改变，其切点可用于筛查青少年血脂谱改变的风险。
