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巴西儿童和青少年的总胆固醇和低密度脂蛋白改变：一项患病率荟萃分析。

Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis.

机构信息

Escola de Enfermagem, Programa de Pós-graduação em Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Departamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

出版信息

Arch Endocrinol Metab. 2023 Jan 18;67(1):19-44. doi: 10.20945/2359-3997000000508. Epub 2022 Aug 4.

DOI:10.20945/2359-3997000000508
PMID:35929904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9983790/
Abstract

OBJECTIVE

The aim of the present study was to evaluate the prevalence of total cholesterol (TC) and low-density lipoprotein (LDL) alterations in children and adolescents in Brazil.

SUBJECTS AND METHODS

A systematic review and meta-analysis of prevalence. The search for articles was carried out in the databases: Medline (PubMed), Embase, Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (Lilacs). The meta-analysis was performed using the random effects model. The I test was used to identify heterogeneity.

RESULTS

The present metanalysis revealed a significant prevalence of altered lipid profile in children and adolescents in Brazil. Regarding lipoprotein fractions, the prevalence of altered TC level was 27.47% (95% CI 24.36-30.82), and a smaller prevalence was observed for LDL cholesterol (19.29% - 95% CI 15.21-24.16). The models revealed high heterogeneity (I = 99%; p < 0.01), however the precise source of it was not identified; although type of school, age group, year and the region of Brazil appeared to influence the estimations of altered lipid profiles.

CONCLUSION

An important prevalence of lipid alterations was observed among Brazilian children and adolescents. Those results reinforce the importance of knowing the lipid profile of children and adolescents to perform early interventions for this public.

摘要

目的

本研究旨在评估巴西儿童和青少年总胆固醇（TC）和低密度脂蛋白（LDL）改变的患病率。

方法

系统评价和荟萃分析患病率。在 Medline（PubMed）、Embase、科学电子图书馆在线（SciELO）、拉丁美洲和加勒比健康科学文献（Lilacs）数据库中进行了文献检索。使用随机效应模型进行荟萃分析。使用 I 检验来识别异质性。

结果

本荟萃分析显示，巴西儿童和青少年的血脂异常患病率显著。关于脂蛋白亚类，TC 水平改变的患病率为 27.47%（95%CI 24.36-30.82），LDL 胆固醇的患病率较低（19.29%-95%CI 15.21-24.16）。模型显示存在高度异质性（I = 99%；p < 0.01），但未确定其确切来源；尽管学校类型、年龄组、年份和巴西地区似乎影响了血脂异常谱的估计。

结论

巴西儿童和青少年中存在重要的血脂异常流行率。这些结果强调了了解儿童和青少年的血脂谱的重要性，以便为该人群进行早期干预。

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