Desai A G, Thakur M L
Department of Radiation Therapy and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Crit Rev Clin Lab Sci. 1986;24(2):95-122. doi: 10.3109/10408368609110271.
During the past few years, the clinical and experimental applications of autologous blood cells labeled with gamma-emitting radionuclides, i.e., technetium-99m (Tc-99m) and indium-111 (In-111) have continued to grow rapidly. Investigations have centered around developing techniques that would label blood cells efficiently without alteration of cell viability and their pathophysiologic integrity. Experimental and clinical applications have been aimed at the studies of in vivo cell kinetics and detecting abnormal lesions by external imaging. These will be discussed in detail together with their advantages and disadvantages, and the future directions will be outlined.
在过去几年中，用发射γ射线的放射性核素（即锝-99m（Tc-99m）和铟-111（In-111））标记的自体血细胞的临床和实验应用一直在迅速增长。研究主要集中在开发能够有效标记血细胞而不改变细胞活力及其病理生理完整性的技术上。实验和临床应用旨在研究体内细胞动力学以及通过外部成像检测异常病变。将详细讨论这些应用及其优缺点，并概述未来的发展方向。
