Recommended method for indium-111 platelet survival studies. International Committee for Standardization in Hematology. Panel on Diagnostic Applications of Radionuclides.

Radioactive indium (111In) has been introduced as an alternative to 51Cr as a platelet label because of its shorter half-life, higher photon yield and greater affinity for platelets. Furthermore, platelet labelling with 111In is possible at lower platelet counts than with 51Cr. In healthy individuals, the kinetics of simultaneously injected 111In-labeled and 51Cr-labeled platelets are similar. The document describes the technical and analytic aspects of platelet survival determination with 111In-labeled platelets and is intended to supplement the previously published recommendations for platelet survival studies.