Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
BJOG. 2018 Jan;125(1):55-62. doi: 10.1111/1471-0528.14711. Epub 2017 Jun 14.
Endometriosis constitutes a significant burden on the quality of life of women, their families and healthcare systems. The objective of this study is to describe the real-world epidemiology of endometriosis in an unselected low-risk population in Israel.
Retrospective population-based study.
The computerised databases of Maccabi Healthcare Services (MHS), a 2-million-member healthcare provider representing a quarter of the Israeli population.
The crude point prevalence (31 December 2015; diagnosed since 1998) and annual incidence (2000-2015) rates of diagnosed endometriosis (ICD-9-CM 617.xx) were assessed among women aged 15-55 years. Prevalent patients were characterised in terms of sociodemographic and clinical characteristics, including validated MHS infertility and chronic disease registries.
Prevalence and incidence of diagnosed endometriosis in MHS.
The point prevalence of endometriosis [n = 6146, mean age 40.4 ± 8.0 years (SD)] was 10.8 per 1000 (95% CI 10.5-11.0). Women aged 40-44 years had the highest prevalence rate of 18.6 per 1000 (95% CI 17.7-19.5). Infertility was documented in 37% of patients. A total of 6045 patients were included in the cohort of newly-diagnosed endometriosis (mean age 34.0 ± 8.1 years), corresponding to an average annual incidence rate of 7.2 per 10 000 (95% CI 6.5-8.0).
We observed a substantially lower prevalence of diagnosed endometriosis compared with previous reports in high-risk populations, in line with population-based estimates from European databases (range 0.8-1.8%). Further characterisation of this cohort may help to understand what affects the prevalence of endometriosis in Israel, and to promote earlier diagnosis and improve management in clinical practice.
Endometriosis diagnosed in 1% of women, according to a large population-based study in a community setting.
子宫内膜异位症严重影响女性及其家庭和医疗保健系统的生活质量。本研究旨在描述以色列未选择的低风险人群中子宫内膜异位症的真实世界流行病学。
回顾性基于人群的研究。
Maccabi 医疗保健服务（MHS）的计算机数据库，该服务是一个拥有 200 万成员的医疗保健提供商，代表了以色列人口的四分之一。
评估了 15-55 岁女性中诊断出的子宫内膜异位症（ICD-9-CM 617.xx）的粗点患病率（2015 年 12 月 31 日；自 1998 年以来诊断出）和年发病率（2000-2015 年）。患有子宫内膜异位症的患者的特征包括社会人口统计学和临床特征，包括经过验证的 MHS 不孕和慢性疾病登记处。
MHS 诊断出的子宫内膜异位症的患病率和发病率。
子宫内膜异位症的点患病率[n=6146，平均年龄 40.4±8.0 岁（SD）]为 10.8/1000（95%CI 10.5-11.0）。40-44 岁的女性患病率最高，为 18.6/1000（95%CI 17.7-19.5）。37%的患者有不孕病史。共有 6045 名患者被纳入新诊断为子宫内膜异位症的队列（平均年龄 34.0±8.1 岁），对应于平均每年 7.2/10000（95%CI 6.5-8.0）的发病率。
我们观察到与高危人群中的先前报告相比，诊断出的子宫内膜异位症的患病率明显较低，与欧洲数据库的基于人群的估计值一致（范围为 0.8-1.8%）。进一步对该队列进行特征描述可能有助于了解哪些因素影响以色列子宫内膜异位症的患病率，并促进临床实践中更早的诊断和改善管理。
根据社区环境中的一项大型基于人群的研究，有 1%的女性被诊断出患有子宫内膜异位症。
