Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
J Hematol Oncol. 2023 Jul 14;16(1):74. doi: 10.1186/s13045-023-01463-z.
Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diagnosis and therapeutic methods for cancer treatments. The development of new cancer treatments has become a crucial aspect of medical advancements. Nanobots, as one of the most promising applications of nanomedicines, are at the forefront of multidisciplinary research. With the progress of nanotechnology, nanobots enable the assembly and deployment of functional molecular/nanosized machines and are increasingly being utilized in cancer diagnosis and therapeutic treatment. In recent years, various practical applications of nanobots for cancer treatments have transitioned from theory to practice, from in vitro experiments to in vivo applications. In this paper, we review and analyze the recent advancements of nanobots in cancer treatments, with a particular emphasis on their key fundamental features and their applications in drug delivery, tumor sensing and diagnosis, targeted therapy, minimally invasive surgery, and other comprehensive treatments. At the same time, we discuss the challenges and the potential research opportunities for nanobots in revolutionizing cancer treatments. In the future, medical nanobots are expected to become more sophisticated and capable of performing multiple medical functions and tasks, ultimately becoming true nanosubmarines in the bloodstream.
早期发现和诊断许多癌症是非常具有挑战性的。癌症的晚期检测总是导致高死亡率。开发新的、更敏感和有效的诊断和治疗方法对于癌症治疗至关重要。癌症治疗的新方法的发展已成为医学进步的关键方面。纳米机器人作为纳米医学最有前途的应用之一,处于多学科研究的前沿。随着纳米技术的进步,纳米机器人能够组装和部署功能分子/纳米级机器,并越来越多地应用于癌症诊断和治疗。近年来,纳米机器人在癌症治疗中的各种实际应用已经从理论走向实践,从体外实验走向体内应用。本文综述和分析了纳米机器人在癌症治疗方面的最新进展,特别强调了它们的关键基本特征及其在药物输送、肿瘤传感和诊断、靶向治疗、微创手术和其他综合治疗中的应用。同时,我们讨论了纳米机器人在癌症治疗方面的挑战和潜在的研究机会。未来,医疗纳米机器人有望变得更加复杂,能够执行多种医疗功能和任务,最终成为血液中的真正纳米潜艇。