Britto Isadora, Couto Heloiza, de Paiva Bruna Regis, de Brito Jessyca S, Alvarenga Livia, Cardozo Ludmila F M F, Leite Paulo Emilio Correa, Berretta Andresa A, Ribeiro-Alves Marcelo, Delgado Virgílio Pimentel, Cunha Danielle Figueiredo da, Sanz Carmen Lucia, Nakao Lia S, Mafra Denise
Graduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil.
Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói 24030-215, RJ, Brazil.
Life (Basel). 2025 May 30;15(6):891. doi: 10.3390/life15060891.
Foods such as L. and propolis can attenuate inflammation in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This study aimed to evaluate the effects of microcapsules loaded with L. and propolis on inflammatory markers and uremic toxins in patients undergoing HD. In this randomized, double-blind clinical trial, 40 patients were divided into two groups: an intervention group (137 mg/day of Curcuma and 500 mg/day of green propolis) in the form of microcapsules, and a placebo group, both administered for 8 weeks. Cytokines were analyzed using a multiplex assay (Bio-Plex Magpix). Malondialdehyde was evaluated as a marker of lipid peroxidation. Uremic toxins were analyzed by reversed-phase high-performance liquid chromatography. Demographic and clinical data were obtained from medical records. A total of 38 patients completed the study: 18 were in the intervention group (49 ± 16.2 years; 8 men) and 20 were in the control group (49 ± 18.7 years; 10 men). There was a reduction in levels of C-reactive protein ( = 0.026) and MIP-1 ( = 0.019) in the intervention group. No change in uremic toxins was observed. In conclusion, the intervention with microcapsules containing L. and green propolis showed potential anti-inflammatory effects in patients with CKD undergoing HD. These findings warrant investigation in larger, long-term trials.
诸如姜黄和蜂胶之类的食物可以减轻接受血液透析（HD）的慢性肾脏病（CKD）患者的炎症。本研究旨在评估负载姜黄和蜂胶的微胶囊对接受HD治疗的患者炎症标志物和尿毒症毒素的影响。在这项随机、双盲临床试验中，40名患者被分为两组：干预组（以微胶囊形式给予137毫克/天姜黄和500毫克/天绿蜂胶）和安慰剂组，两组均给药8周。使用多重检测法（Bio-Plex Magpix）分析细胞因子。评估丙二醛作为脂质过氧化的标志物。通过反相高效液相色谱法分析尿毒症毒素。从病历中获取人口统计学和临床数据。共有38名患者完成了研究：18名在干预组（49±16.2岁；8名男性），20名在对照组（49±18.7岁；10名男性）。干预组中C反应蛋白（P = 0.026）和MIP-1（P = 0.019）水平降低。未观察到尿毒症毒素有变化。总之，含姜黄和绿蜂胶的微胶囊干预对接受HD治疗的CKD患者显示出潜在的抗炎作用。这些发现值得在更大规模的长期试验中进行研究。
