NR5A2发现可阻断胰腺导管腺癌肿瘤生长的化合物。
NR5A2 discovering compounds that block tumor growth in PDAC.
作者信息
Fletterick Robert
机构信息
Department of Biochemistry, School of Medicine, UCSF, San Francisco, California.
出版信息
J Surg Oncol. 2017 Jul;116(1):89-93. doi: 10.1002/jso.24639. Epub 2017 Apr 26.
Abstract
Pancreatic cancers depend on driver molecules, oncogene proteins such as RAS. NR5A2 protein is a transcription factor and either activates or inhibits transcription through actions at hundreds of enhancers. It has unusual properties with effects appearing in multiple signaling networks. NR5A2 is a pluripotency reprogramming factor in the class nuclear receptor. Its controlling hormone is PIP3. Experiments suggest NR5A2 activation drives PDAC and inhibitors blunt cancer cell proliferation.
摘要
胰腺癌依赖于驱动分子，如RAS等致癌基因蛋白。NR5A2蛋白是一种转录因子，通过作用于数百个增强子来激活或抑制转录。它具有不同寻常的特性，其效应出现在多个信号网络中。NR5A2是核受体类中的一种多能性重编程因子。其调控激素是PIP3。实验表明，NR5A2的激活会驱动胰腺导管腺癌（PDAC），而抑制剂会抑制癌细胞增殖。
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