Tatay-Manteiga Amparo, Balanzá-Martínez Vicent, Bristot Giovana, Tabarés-Seisdedos Rafael, Kapczinski Flavio, Cauli Omar
Service of Psychiatry, University General Hospital, Valencia, Spain.
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain; Service of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:194-201. doi: 10.1016/j.pnpbp.2017.04.028. Epub 2017 Apr 23.
Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD.
Euthymic BD-I patients were grouped according to their level of functioning in early-stage (n=25) and late-stage (n=23), and compared to healthy siblings (n=23) and genetically unrelated healthy controls (n=21). Neurotrophin (neurotrophin-3 and BDNF) concentration and biomarkers of inflammation, including cytokines (IL-6, IL-10 and TNF-α), leukocytes count and acute phase proteins, were measured.
IL-10 concentration was significantly increased in early-stage patients compared to late-stage patients, healthy siblings and controls whereas TNF-α concentration was significantly increased in late-stage patients compared to controls. Total leukocytes, neutrophil and monocyte count were significantly increased in late-stage patients compared to healthy siblings and controls. The concentration of IL-6, neurotrophin-3 and BDNF was unchanged in euthymia. Healthy siblings did not show significant changes in any biomarker.
The concentration of IL-10, TNF-α, neutrophil and monocytes subtype count in blood is altered in patients with BD during euthymic state. The link between peripheral inflammation and different stages in BD deserves further studies.
血清细胞因子的变化和神经营养因子浓度的改变与双相情感障碍（BD）有关。我们的目的是根据BD的临床阶段分析外周血生物标志物。
将处于心境正常期的BD-I患者根据其功能水平分为早期组（n = 25）和晚期组（n = 23），并与健康同胞（n = 23）和无亲缘关系的健康对照者（n = 21）进行比较。测量神经营养因子（神经营养因子-3和脑源性神经营养因子）浓度以及炎症生物标志物，包括细胞因子（IL-6、IL-10和TNF-α）、白细胞计数和急性期蛋白。
与晚期患者、健康同胞和对照组相比，早期患者的IL-10浓度显著升高；而与对照组相比，晚期患者的TNF-α浓度显著升高。与健康同胞和对照组相比，晚期患者的白细胞总数、中性粒细胞和单核细胞计数显著增加。在心境正常期，IL-6、神经营养因子-3和脑源性神经营养因子的浓度没有变化。健康同胞在任何生物标志物上均未显示出显著变化。
处于心境正常状态的BD患者血液中IL-10、TNF-α、中性粒细胞和单核细胞亚型计数的浓度发生了改变。外周炎症与BD不同阶段之间的联系值得进一步研究。
