对氧磷酶1基因多态性与中国女性人群患乳腺癌风险增加相关。
Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women.
作者信息
Wu Junrong, Fang Min, Zhou Xiaoping, Zhu Bo, Yang Zhi
机构信息
Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530022, Guangxi, China.
出版信息
Oncotarget. 2017 Apr 11;8(15):25362-25371. doi: 10.18632/oncotarget.15911.
In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M carrier status and M alleles, were associated with an increased risk of breast cancer. In addition, the M allele was associated with postmenopausal status and increased nodal involvement. In contrast, none of the Q192R genotypes or alleles were associated with a change in breast cancer risk, or with any of the clinicopathological parameters. These results indicate that PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.
在本研究中，我们在中国南方广西地区的365例女性乳腺癌患者和378例健康对照中，探究了对氧磷酶1（PON1）L55M和Q192R基因多态性与乳腺癌风险之间的关联。LM杂合基因型和MM纯合基因型，以及M携带状态和M等位基因，均与乳腺癌风险增加相关。此外，M等位基因与绝经后状态及淋巴结受累增加相关。相比之下，Q192R基因型或等位基因均与乳腺癌风险变化或任何临床病理参数无关。这些结果表明，PON1 L55M基因多态性可能与乳腺癌风险相关，并有可能作为中国部分女性人群肿瘤预后的有用遗传标志物。
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