Lee Young Ho, Kim Jae-Hoon, Seo Young Ho, Choi Sung Jae, Ji Jong Dae, Song Gwan Gyu
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea,
Neurol Sci. 2015 Jan;36(1):11-20. doi: 10.1007/s10072-014-1979-y. Epub 2014 Oct 10.
This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 % CI = 0.923-1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 % CI = 0.884-1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 % CI = 0.910-1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 % CI = 0.889-1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.
本研究旨在调查对氧磷酶1（PON1）Q192R和L55M基因多态性是否与肌萎缩侧索硬化症（ALS）易感性相关。我们对PON1 Q192R和L55M基因多态性与ALS之间的关联进行了荟萃分析。本研究纳入了八项关于PON1 Q192R基因多态性研究中的2831例患者和3123例对照，以及七项关于PON1 L55M基因多态性研究中的相关对象。荟萃分析显示，在所有研究对象中，ALS与PON1 192R等位基因（比值比[OR]=1.052，95%可信区间[CI]=0.923 - 1.207，p=0.447）以及PON1 55M等位基因（OR=1.015，95%CI=0.884 - 1.164，p=0.837）均无关联。同样，使用隐性、显性或纯合子对比模型时，ALS与PON1 Q192R和L55M基因多态性之间也未发现关联。按种族分层显示，在欧洲人群中，ALS与PON1 192R等位基因（OR=1.058，95%CI=0.910 - 1.231，p=0.464）以及PON1 55M等位基因（OR=1.027，95%CI=0.889 - 1.185，p=0.721）均无关联。这项荟萃分析表明，在欧洲人群中，PON1 Q192R和L55M基因多态性与ALS易感性之间缺乏关联。
