Chen Lei, Lu Wei, Fang Lu, Xiong Hu, Wu Xun, Zhang Meng, Wu Song, Yu Dexin
Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Department of Urology, Anhui Medical University Graduate School, Hefei, Anhui, People's Republic of China.
Onco Targets Ther. 2016 Mar 4;9:1151-8. doi: 10.2147/OTT.S96990. eCollection 2016.
L55M polymorphism in Paraoxonase 1 (PON1) has been regarded as a risk factor for many cancer types. Nevertheless, the results remain controversial and inconclusive. We therefore performed a meta-analysis of all eligible case-control studies to evaluate the association between L55M polymorphism and cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. Finally, a total of 5,627 cases and 6,390 controls, arising from 21 case-control studies, were enrolled in our study. Significant associations between PON1-L55M polymorphism and overall cancer risk were identified in all genetic models. In the stratified analyses by cancer type, PON1-L55M polymorphism was a risk factor for breast cancer in all genetic models, prostate cancer in the heterozygote model (ML vs LL: OR =1.304, 95% CI =1.049-1.620, P heterogeneity=0.067), and ovarian cancer in the recessive model (MM vs ML/LL: OR =1.526, 95% CI =1.110-2.097, P heterogeneity=0.464). Similarly, an increased risk was also identified for the Caucasian population in the heterozygote comparison and homozygote models, and hospital-based controls in all genetic models. To sum up, our study suggests that the PON1-L55M allele increased the risk of cancer. Future well-designed studies with larger sample sizes are warranted to further verify these findings.
对氧磷酶1（PON1）中的L55M多态性被认为是多种癌症类型的危险因素。然而，结果仍存在争议且尚无定论。因此，我们对所有符合条件的病例对照研究进行了荟萃分析，以评估L55M多态性与癌症风险之间的关联。采用比值比（OR）和95%置信区间（CI）来评估关联强度。最终，我们的研究纳入了来自21项病例对照研究的5627例病例和6390例对照。在所有遗传模型中均发现PON1-L55M多态性与总体癌症风险之间存在显著关联。在按癌症类型进行的分层分析中，PON1-L55M多态性在所有遗传模型中都是乳腺癌的危险因素，在杂合子模型中是前列腺癌的危险因素（ML与LL相比：OR = 1.304，95% CI = 1.049 - 1.620，P异质性 = 0.067），在隐性模型中是卵巢癌的危险因素（MM与ML/LL相比：OR = 1.526，95% CI = 1.110 - 2.097，P异质性 = 0.464）。同样，在杂合子比较和纯合子模型中，白种人群以及在所有遗传模型中基于医院的对照人群的癌症风险也有所增加。综上所述，我们的研究表明PON1-L55M等位基因增加了癌症风险。未来有必要开展设计更完善、样本量更大的研究来进一步验证这些发现。
