Khew-Goodall Y, Hemmings B A
Friedrich Miescher-Institut, Basel, Switzerland.
FEBS Lett. 1988 Oct 10;238(2):265-8. doi: 10.1016/0014-5793(88)80493-9.
The mRNAs encoding the catalytic subunits of the type 1 phosphatase and the alpha and beta forms of phosphatase 2A (termed 2A alpha and 2A beta) were detected in all the porcine tissues examined (brain, heart, muscle, liver, kidney and ovaries). Total phosphatase 2A transcripts were about 10 times more abundant in brain and heart than in the other tissues while the distribution of phosphatase 1 mRNA showed significantly less variation. Phosphatase 2A alpha mRNA was about 10 times more abundant than phosphatase 2A beta mRNA in most tissues. Similarly, both the alpha and beta forms of the mRNA of the catalytic subunit of the phosphatase 2A were present in all the rat tissues examined. In addition to the 2 kb mRNA generally expressed, rat tissues also express a 2.8 kb mRNA related to 2A alpha and a 1.3 kb mRNA related to 2A beta.
在所检测的所有猪组织（脑、心脏、肌肉、肝脏、肾脏和卵巢）中，均检测到了编码1型磷酸酶催化亚基以及磷酸酶2A的α和β形式（分别称为2Aα和2Aβ）的信使核糖核酸（mRNA）。脑和心脏中的总磷酸酶2A转录本含量比其他组织中约高10倍，而磷酸酶1 mRNA的分布变化则明显较小。在大多数组织中，磷酸酶2Aα mRNA的含量比磷酸酶2Aβ mRNA约高10倍。同样，在所检测的所有大鼠组织中均存在磷酸酶2A催化亚基的α和β形式的mRNA。除了通常表达的2 kb mRNA外，大鼠组织还表达与2Aα相关的2.8 kb mRNA以及与2Aβ相关的1.3 kb mRNA。
