Bournazos Stylianos, Wang Taia T, Dahan Rony, Maamary Jad, Ravetch Jeffrey V
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10065; email:
Annu Rev Immunol. 2017 Apr 26;35:285-311. doi: 10.1146/annurev-immunol-051116-052433.
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.
IgG抗体通过Fab结构域的抗原特异性偶联与Fc-Fc受体相互作用介导的信号转导,发挥多种免疫功能。事实上,通过I型和II型Fc受体实现的平衡IgG信号传导,对于控制促炎、抗炎和免疫调节过程是必需的。在本综述中,我们讨论了IgG-Fc受体相互作用的调控机制,强调了Fc受体介导的效应功能的多样性,这些功能调节免疫和炎症,决定对感染和自身免疫的易感性以及对基于抗体的治疗和疫苗的反应性。