基质金属蛋白酶-13在人类颞下颌关节盘紊乱和骨关节炎中的表达
Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis.
作者信息
Perotto Juliano Henrique, Camejo Flavio de Alcantara, Doetzer Andrea Duarte, Almeida Luis Eduardo, Azevedo Marina, Olandoski Márcia, Noronha Lucia, Trevilatto Paula Cristina
机构信息
a School of Health and Biosciences , Pontifícia Universidade Católica do Paraná (PUCPR) , Curitiba , Brazil.
b School of Dentistry , Marquette University Milwaukee , Milwaukee , WI , USA.
出版信息
Cranio. 2018 May;36(3):161-166. doi: 10.1080/08869634.2017.1315511. Epub 2017 Apr 26.
OBJECTIVE
MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis.
METHODS
Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups.
RESULTS
There was no statistically significant difference for the area of MMP-13 immunostaining between the control group, ADDwR, and ADDwoR, nor between groups with and without osteoarthrosis.
CONCLUSION
This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc displacement or osteoarthrosis.
目的
基质金属蛋白酶-13（MMP-13）可分解胶原蛋白，而胶原蛋白是颞下颌关节（TMJ）关节盘的主要成分。本研究评估了MMP-13在伴可复性盘前移位（ADDwR）、不可复性盘前移位（ADDwoR）患者以及存在TMJ骨关节炎患者中的表达情况。
方法
收集39例人类颞下颌关节盘样本，并按两种方式分组：ADDwR组（21个样本）、ADDwoR组（10个样本）和对照组（8个样本）；骨关节炎组（10个样本）和无骨关节炎组（29个样本）。对TMJ关节盘进行免疫染色，并在组间进行统计学比较。
结果
对照组、ADDwR组和ADDwoR组之间，以及有骨关节炎组和无骨关节炎组之间，MMP-13免疫染色面积无统计学显著差异。
结论
本研究表明，MMP-13在人类TMJ盘移位或骨关节炎的胶原蛋白降解过程中无显著作用。
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