Flückiger R, Laifer G, Itin P, Meyer B, Lang C
St. Claraspital Basel, Switzerland.
Gastroenterology. 1994 Feb;106(2):506-8. doi: 10.1016/0016-5085(94)90612-2.
A 30-year-old man with ulcerative colitis developed oral hairy leukoplakia (OHL). Serological examination for human immunodeficiency virus (HIV)-1 and HIV-2 infection showed no abnormalities. Biopsy specimen of the lateral tongue showed ballooned prickle cells, and electron microscopy revealed herpes-type viruses. Immunologic investigation of the patient showed a marked decrease in T-helper cells as a result of immunosuppressive regimen. The present report appears to be the first well-documented case of OHL in an HIV-negative patient with ulcerative colitis. OHL may be a marker for severe immunosuppression but is not necessarily associated with HIV infection. Patients with iatrogenic immunosuppression should be monitored for OHL. Concerning the marked decrease in T-helper cells in this case, the presence of OHL may imply the examination of T-lymphocyte subsets in patients such as HIV-infected individuals or in organ transplant recipients.
一名患有溃疡性结肠炎的30岁男性患上了口腔毛状白斑（OHL）。针对人类免疫缺陷病毒（HIV）-1和HIV-2感染的血清学检查未发现异常。舌外侧活检标本显示棘细胞气球样变，电子显微镜检查发现疱疹型病毒。对该患者的免疫学调查显示，由于免疫抑制治疗方案，辅助性T细胞显著减少。本报告似乎是第一例有充分记录的HIV阴性溃疡性结肠炎患者发生OHL的病例。OHL可能是严重免疫抑制的一个标志，但不一定与HIV感染相关。医源性免疫抑制患者应监测是否发生OHL。关于该病例中辅助性T细胞的显著减少，OHL的存在可能意味着对HIV感染个体或器官移植受者等患者进行T淋巴细胞亚群检查。
