黑人和白人人群三年来肾素、心血管及炎症标志物的变化：南非城乡心脏代谢与生活方式研究（SABPA研究）
Change in renin, cardiovascular and inflammatory markers over three years in a black and white population: the SABPA study.
作者信息
Swart Rijané, van Rooyen Johannes M, Mels Catharina M C
机构信息
Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, 2522, South Africa.
出版信息
BMC Cardiovasc Disord. 2017 Apr 26;17(1):104. doi: 10.1186/s12872-017-0538-x.
BACKGROUND
To investigate if percentage change (%∆) in renin over a 3 year follow-up is associated with %∆ in cardiovascular and inflammatory markers in a low renin bi-ethnic group.
METHODS
Blood pressure, active renin, C-reactive protein and interleukin-6 levels of 73 black and 81 white teachers were measured at baseline and after 3 years.
RESULTS
In the black group, %∆ renin was inversely associated with %∆ systolic blood pressure (β = -0.27; p = 0.011). In the white group %∆ renin was inversely associated with %∆interleukin-6 (β = -0.24; p = 0.005).
CONCLUSIONS
These prospective results indicate that a decrease in renin over time is associated with an increase in blood pressure in a low renin black South African cohort.
背景
调查在低肾素双种族群体中，3年随访期间肾素的百分比变化（%∆）是否与心血管和炎症标志物的百分比变化相关。
方法
在基线和3年后测量了73名黑人教师和81名白人教师的血压、活性肾素、C反应蛋白和白细胞介素-6水平。
结果
在黑人组中，肾素%∆与收缩压%∆呈负相关（β = -0.27；p = 0.011）。在白人组中，肾素%∆与白细胞介素-6%∆呈负相关（β = -0.24；p = 0.005）。
结论
这些前瞻性结果表明，在低肾素的南非黑人队列中，随着时间的推移肾素降低与血压升高相关。
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