Correro M Rita, Dudal Yves, Corvini Philippe F-X, Shahgaldian Patrick
University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Institute of Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz.
INOFEA AG, Hochbergerstasse 60c, CH-4057 Basel.
Chimia (Aarau). 2017 Apr 26;71(4):243-245. doi: 10.2533/chimia.2017.243.
A series of synthetic nanomaterials capable of molecular recognition and/or biocatalysis have been produced by exploiting the self-sorting, self-assembly and polycondensation of organosilane building blocks around protein templates. The established methodology allows for the production of thin organosilica layers of controlled thickness, down to nanometer precision. Fully synthetic virus recognition materials have been shown to specifically bind their target virus down to picomolar concentrations. The shielding of natural enzymes allowed producing nanobiocatalysts functioning under harsh operational conditions.
通过利用围绕蛋白质模板的有机硅烷结构单元的自分类、自组装和缩聚反应，制备了一系列能够进行分子识别和/或生物催化的合成纳米材料。既定的方法能够制备厚度可控的薄有机硅层，精度可达纳米级。已证明完全合成的病毒识别材料能够特异性结合其目标病毒，最低至皮摩尔浓度。对天然酶的屏蔽使得能够制备在苛刻操作条件下发挥作用的纳米生物催化剂。
