Weidle Ulrich H, Birzele Fabian, Kollmorgen Gwen, Rüger Rüdiger
Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
Roche Innovation Center Basel, F. Hofman La Roche, Basel, Switzerland.
Cancer Genomics Proteomics. 2017 May-Jun;14(3):143-160. doi: 10.21873/cgp.20027.
The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be uncovered. A large body of evidence has revealed their essential role in all stages of cancirogenesis and metastasis. In this review we focus on the role of lncRNAs in metastasis. We grouped selected lncRNAs into three categories based on in vitro and in vivo mode of action-related studies and clinical relevance for metastasis. Grouped according to their mode of action, in category I we discuss lncRNAs such as CCAT2, DREH, LET, NKILA, treRNA, HOTAIR, H19, FENDRR, lincROR, MALAT, GClnc1, BCAR4, SCHLAP1 and lncRNA ATP, all lncRNAs with in vitro and in vivo metastasis-related data and clinical significance. In category II we discuss lncRNAs CCAT1, PCAT1, PTENgp1, GPLINC, MEG3, ZEB2-AS, LCT13, ANRIL, NBAT1 and lncTCF7 all characterized by their mode of action in vitro and clinical significance, but pending or preliminary in vivo data. Finally, under category III, we discuss lncRNAs BANCR, FRLnc1, SPRY4-IT1 and LIMT with partially or poorly-resolved mode of action and varying degree of validation in clinical metastasis. Finally we discuss metastasis-related translational aspects of lncRNAs.
在过去几年中，长链非编码RNA作为“垃圾RNA”和转录噪音的观念已逐渐被其在多种生理过程中作为已验证靶点的作用所取代。然而，对于绝大多数长链非编码RNA而言，其确切的作用模式和生理功能仍有待揭示。大量证据表明它们在癌症发生和转移的各个阶段都发挥着重要作用。在本综述中，我们聚焦于长链非编码RNA在转移中的作用。基于与体外和体内作用模式相关的研究以及转移的临床相关性，我们将所选的长链非编码RNA分为三类。根据其作用模式进行分类，在第一类中，我们讨论如CCAT2、DREH、LET、NKILA、treRNA、HOTAIR、H19、FENDRR、lincROR、MALAT、GClnc1、BCAR4、SCHLAP1和lncRNA ATP等长链非编码RNA，所有这些长链非编码RNA都有与体外和体内转移相关的数据及临床意义。在第二类中，我们讨论CCAT1、PCAT1、PTENgp1、GPLINC、MEG3、ZEB2 - AS、LCT13、ANRIL、NBAT1和lncTCF7等长链非编码RNA，它们都以其体外作用模式和临床意义为特征，但体内数据尚待完善或仅为初步结果。最后，在第三类中，我们讨论作用模式部分或尚未完全明确且在临床转移中验证程度各异的长链非编码RNA，如BANCR、FRLnc1、SPRY4 - IT1和LIMT。最后，我们讨论长链非编码RNA与转移相关的转化医学方面。
