Sun Cong, Pezic Angela, Mackey David A, Carlin John B, Kemp Andrew, Ellis Justine A, Cameron Fergus J, Rodda Christine P, Dwyer Terence, Coroneo Minas T, Ponsonby Anne-Louise
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1146-1153. doi: 10.1158/1055-9965.EPI-16-0846. Epub 2017 Apr 26.
Conjunctival ultraviolet autofluorescence (CUVAF) area detected from UVAF photographs is a recently developed potential marker for past sun exposure, but its relationship with sun-related factors has not been fully investigated. The study included 339 healthy children ages 5 to 15 years in Melbourne, Australia. Data were collected by questionnaire and examination at school. CUVAF area was measured using a computer program and analyzed as a continuous and dichotomous outcome (any/none). Fifty-three children (15.6%) had detectable CUVAF, and the youngest age at which a child showed sun damage was 8 years. Compared with silicone skin cast score, there was good inter-grader agreement on CUVAF grading, with Cohen kappa 0.85 [95% confidence interval (CI), 0.65-1.00] for total CUVAF area using both eye photographs. Perfect intra-grader agreement was achieved. Fairer pigmentation, including medium/fair skin color [adjusted odds ratio (AOR), 3.42; 95% CI, 1.02-11.48 vs. dark/olive] and blue/gray eye color (AOR, 4.07; 95% CI, 1.73-9.55 vs. brown) was associated with increased odds of CUVAF. Increasing lifetime sunburn number (e.g., AOR, 2.89; 95% CI, 1.14-7.35 and 4.29; 1.04-17.76 for sunburns 2 to 4 and ≥ 5 times, respectively, vs. no sunburns, trend = 0.004) and freckling by the end of last summer were associated with increased odds of CUVAF. CUVAF area can be an objective measure of past sun exposure in pediatric populations for future research. To our knowledge, this is the first pediatric study that evaluated associations of sun-related risk factors with CUVAF. .
从紫外线自体荧光（UVAF）照片中检测到的结膜紫外线自体荧光（CUVAF）面积是一种最近开发的过去阳光暴露潜在标志物，但其与阳光相关因素的关系尚未得到充分研究。该研究纳入了澳大利亚墨尔本339名5至15岁的健康儿童。数据通过问卷调查和在学校进行检查收集。使用计算机程序测量CUVAF面积，并将其作为连续和二分结果（有/无）进行分析。53名儿童（15.6%）有可检测到的CUVAF，儿童出现阳光损伤的最小年龄为8岁。与硅胶皮肤铸型评分相比，CUVAF分级的分级者间一致性良好，使用双眼照片对总CUVAF面积的Cohen κ系数为0.85[95%置信区间（CI），0.65 - 1.00]。分级者内一致性完美。更白皙的肤色，包括中等/白皙肤色[调整优势比（AOR），3.42；95%CI，1.02 - 11.48，与深色/橄榄色相比]和蓝/灰色眼睛颜色（AOR，4.07；95%CI，1.73 - 9.55，与棕色相比）与CUVAF几率增加相关。一生中晒伤次数增加（例如，晒伤2至4次和≥5次的AOR分别为2.89；95%CI，1.14 - 7.35和4.29；1.04 - 17.76，与无晒伤相比，趋势 = 0.004）以及去年夏末出现雀斑与CUVAF几率增加相关。CUVAF面积可作为儿科人群过去阳光暴露的客观测量指标，用于未来研究。据我们所知，这是第一项评估阳光相关危险因素与CUVAF关联的儿科研究。
