de la Puente Miriam, Irigoyen-Bañegil Cristina, Ortega Claici Aura, González-Zamora Jorge, Bilbao-Malavé Valentina, Fernandez-Robredo Patricia, Hernández María, Barrio Jesús, García-Layana Alfredo, Recalde Sergio
Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Biomedicines. 2024 Feb 1;12(2):347. doi: 10.3390/biomedicines12020347.
The objective of this study was to evaluate the association of the presence of conjunctival ultraviolet autofluorescence (CUVAF) with the level and progression of myopia and the impact of reduced sunlight exposure during the COVID-19 pandemic confinement (PC).
A retrospective observational study was carried out using three cohorts, children (9-17 years old), young adults (18-25 years old), and adults (>40 years old) with myopia (≤0.75D) and at least three annual eye examinations (before and after PC). All participants underwent an automatic objective refraction and CUVAF area analysis. All the participants filled out a questionnaire regarding lifestyle and myopia history.
The 298 recruited participants showed that during the PC, children's and young adults' myopia progression rate increased on average by -0.50 and -0.30 D/year, respectively, compared with the pre-pandemic level ( < 0.0001 and < 0.01). A significantly greater progression was observed in those with low baseline myopia compared to those with moderate or high myopia ( < 0.01). CUVAF shows its protective effect associated with outdoor activity (OA) with regard to the age of onset of myopia and mean diopters ( < 0.01). In fact, although there were no differences in the increase in diopters between children with and without CUVAF during the PC, those who had CUVAF started with lower gains (-0.3 D/year) compared to those who did not (-0.5 D/year; < 0.05). The myopia treatments (atropine drops, Ortho-K, and MiSight contact lenses) showed a reduction effect in myopic progression rate post-PC in comparison with non-treated children ( < 0.0001, < 0.0001 and < 0.01, respectively).
The strict restriction of OA during PC led to the rate of myopia progression doubling among children and young adults. This progression occurred mainly in children with previously low myopia, and CUVAF, as a biomarker of OA, reflects its potential to provide benefits in the form of recommended behavioral changes to protect against the development of myopia.
本研究的目的是评估结膜紫外线自发荧光（CUVAF）的存在与近视程度和进展的关联，以及新冠疫情封锁（PC）期间阳光暴露减少的影响。
采用回顾性观察研究，对三组队列进行研究，包括近视（≤0.75D）的儿童（9 - 17岁）、青年成人（18 - 25岁）和成年人（>40岁），且至少有三次年度眼部检查（PC之前和之后）。所有参与者均接受自动客观验光和CUVAF面积分析。所有参与者填写了一份关于生活方式和近视病史的问卷。
招募的298名参与者显示，在PC期间，与疫情前水平相比，儿童和青年成人的近视进展率平均分别增加了-0.50和-0.30 D/年（<0.0001和<0.01）。与中度或高度近视者相比，基线近视程度低的人近视进展明显更大（<0.01）。就近视发病年龄和平均屈光度而言，CUVAF显示出其与户外活动（OA）相关的保护作用（<0.01）。事实上，虽然在PC期间有CUVAF和没有CUVAF的儿童屈光度增加没有差异，但有CUVAF的儿童起始增加幅度（-0.3 D/年）低于没有CUVAF的儿童（-0.5 D/年；<0.05）。与未治疗的儿童相比，近视治疗方法（阿托品滴眼液、角膜塑形镜和MiSight隐形眼镜）在PC后显示出降低近视进展率的效果（分别为<0.0001、<0.0001和<0.01）。
PC期间对OA的严格限制导致儿童和青年成人的近视进展率翻倍。这种进展主要发生在先前近视程度低的儿童中，而CUVAF作为OA的生物标志物，反映了其通过推荐行为改变来预防近视发展从而提供益处的潜力。
Zotero 插件
