Jorgensen Josh M, Yang Zhenyu, Lönnerdal Bo, Chantry Caroline J, Dewey Kathryn G
Department of Nutrition, University of California, Davis, Davis, CA;
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Key Laboratory of Trace Element Nutrition, Ministry of Health of China, Beijing, China; and.
J Nutr. 2017 Jun;147(6):1194-1199. doi: 10.3945/jn.116.245803. Epub 2017 Apr 26.
Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection. The postpartum period is a physiologically unique life stage in which the relations between these proteins and other markers of inflammation have not been extensively studied. We aimed to determine whether 2 markers of inflammation [high-sensitivity C-reactive protein (CRP) and α1-acid glycoprotein (AGP)] were associated with ferritin or hepcidin in postpartum women in California. This is a secondary analysis of a randomized controlled iron-intervention trial. Plasma CRP, AGP, ferritin, and hepcidin were analyzed at 2 and 17 wk postpartum in 114 lactating women. We examined Pearson correlation coefficients between all biomarkers at both time points and differences in mean values of ferritin and hepcidin between those with and without elevated CRP and/or AGP. At 2 and 17 wk postpartum, 58% and 26% of women had CRP >5 mg/L and 78% and 29% had AGP >1 g/L, respectively. Neither CRP nor AGP was significantly correlated with ferritin ( = 0.07 and -0.06; = 114 at 2 wk; -0.14 and -0.14; = 95 at 17 wk) or hepcidin ( = 0.18 and -0.03 at 2 wk; -0.05 and -0.14 at 17 wk; > 0.05 for all). At 2 wk, geometric mean plasma ferritin and hepcidin concentrations did not differ between women with and without elevated CRP or AGP ( > 0.5), but at 17 wk women with elevated CRP or AGP had lower mean (95% CI) ferritin and hepcidin than did women without either elevated CRP or AGP [ferritin: 30.3 ng/mL (23.4, 39.1 ng/mL) compared with 40.2 ng/mL (32.9, 49.2 ng/mL); < 0.01; hepcidin: 44.3 ng/mL (32.3, 60.9 ng/mL) compared with 67.6 ng/mL (56.1, 81.5 ng/mL); = 0.02]. Lower ferritin and hepcidin among women with elevated CRP or AGP at 17 wk postpartum suggests that these markers of iron status react differently to physiologic immune activation than to pathologic inflammatory states.
铁蛋白和铁调素是铁状态的标志物，在炎症或感染期间通常会升高。产后时期是一个生理上独特的生命阶段，在这个阶段，这些蛋白质与其他炎症标志物之间的关系尚未得到广泛研究。我们旨在确定两种炎症标志物[高敏C反应蛋白（CRP）和α1-酸性糖蛋白（AGP）]是否与加利福尼亚州产后妇女的铁蛋白或铁调素相关。这是一项随机对照铁干预试验的二次分析。对114名哺乳期妇女在产后2周和17周时的血浆CRP、AGP、铁蛋白和铁调素进行了分析。我们检查了两个时间点所有生物标志物之间的Pearson相关系数，以及CRP和/或AGP升高与未升高的妇女之间铁蛋白和铁调素平均值的差异。在产后2周和17周时，分别有58%和26%的妇女CRP>5 mg/L，78%和29%的妇女AGP>1 g/L。CRP和AGP与铁蛋白均无显著相关性（2周时r = 0.07和 -0.06；n = 114；17周时r = -0.14和 -0.14；n = 95），与铁调素也无显著相关性（2周时r = 0.18和 -0.03；17周时r = -0.05和 -0.14；所有P>0.05）。在2周时，CRP或AGP升高与未升高的妇女之间，血浆铁蛋白和铁调素的几何平均浓度无差异（P>0.5），但在17周时，CRP或AGP升高的妇女的铁蛋白和铁调素平均水平（95%CI）低于CRP和AGP均未升高的妇女[铁蛋白：30.3 ng/mL（23.4，39.1 ng/mL）对比40.2 ng/mL（32.9，49.2 ng/mL）；P<0.01；铁调素：44.3 ng/mL（32.3，60.9 ng/mL）对比67.6 ng/mL（56.1，81.5 ng/mL）；P = 0.02]。产后17周时CRP或AGP升高的妇女中铁蛋白和铁调素水平较低，这表明这些铁状态标志物对生理性免疫激活和病理性炎症状态的反应不同。
