刚果女性在产后/哺乳期各阶段，铜蓝蛋白和α-1-酸性糖蛋白与血清铁蛋白相关，而C反应蛋白则不然。
Ceruloplasmin and Alpha-1-Acid Glycoprotein, but not C-Reactive Protein, Correlate With Serum Ferritin During Various Postpartum/Lactation Periods in Congolese Females.
作者信息
Kuvibidila Solo R, Warrier Rajasekharan P
机构信息
Department of Pediatrics, Division of Hematology/Oncology, Louisiana State University Health Sciences Center, New Orleans, LA.
Department of Pediatrics, Ochsner Clinic Foundation, New Orleans, LA.
出版信息
Ochsner J. 2022 Spring;22(1):26-34. doi: 10.31486/toj.21.0059.
Serum ferritin usually correlates positively with acute phase proteins (APPs), but limited information is available on this association during various postpartum/lactation periods. The objective of this study was to assess the association between serum ferritin and APPs in Congolese females during different postpartum/lactation periods. Serum ferritin, C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), and transferrin saturation (TS) were measured during various postpartum/lactation periods (0.5 to 6, 6.1 to 12, 12.1 to 18, and 18.1 to 24 months) in 131 Congolese females aged 15 to 45 years Mean serum ferritin concentrations were lower in females in the 0.5- to 6-month postpartum/lactation subgroup than in the other 3 subgroups (<0.05). Mean concentrations of hemoglobin, APPs, and TS were not different among the 4 subgroups. While serum ferritin concentrations correlated with Cp (=0.514) and AGP (=0.795) during the 0.5- to 6-month and the 6.1- to 12-month postpartum/lactation periods, respectively (<0.05), they did not correlate with CRP. Multiple regression analysis suggested that Cp explained 25% of serum ferritin variance in the 0.5- to 6-month postpartum/lactation period (39.3% at 0.5 to 4 months) and AGP explained 60.5% of the variance in the 6.1- to 12-month period (3.7% at 0.5 to 4 months). CRP explained <5% of the serum ferritin variance at these postpartum/lactation periods. APPs explained ≤15.1% of serum ferritin variance at postpartum/lactation periods >12 months. Data suggest that the association between serum ferritin and inflammation is dependent on APP type and lactation time. This association may affect the diagnosis of iron deficiency in lactating females. The positive association between serum ferritin and Cp at 0.5 to 6 months postpartum may be necessary to increase liver iron release and erythropoiesis after childbirth.
血清铁蛋白通常与急性期蛋白（APPs）呈正相关，但关于不同产后/哺乳期这一关联的信息有限。本研究的目的是评估刚果女性在不同产后/哺乳期血清铁蛋白与APPs之间的关联。在131名年龄在15至45岁的刚果女性的不同产后/哺乳期（0.5至6个月、6.1至12个月、12.1至18个月和18.1至24个月）测量血清铁蛋白、C反应蛋白（CRP）、α-1-酸性糖蛋白（AGP）、铜蓝蛋白（Cp）和转铁蛋白饱和度（TS）。产后/哺乳期0.5至6个月亚组女性的平均血清铁蛋白浓度低于其他3个亚组（<0.05）。4个亚组之间血红蛋白、APPs和TS的平均浓度无差异。虽然血清铁蛋白浓度在产后/哺乳期0.5至6个月和6.1至12个月期间分别与Cp（=0.514）和AGP（=0.795）相关（<0.05），但与CRP不相关。多元回归分析表明，Cp在产后/哺乳期0.5至6个月解释了血清铁蛋白变异的25%（0.5至4个月时为39.3%），AGP在6.1至12个月期间解释了60.5%的变异（0.5至4个月时为3.7%）。在这些产后/哺乳期，CRP解释的血清铁蛋白变异<5%。在产后/哺乳期>12个月时，APPs解释的血清铁蛋白变异≤15.1%。数据表明，血清铁蛋白与炎症之间的关联取决于APP类型和哺乳时间。这种关联可能会影响哺乳期女性缺铁的诊断。产后0.5至6个月血清铁蛋白与Cp之间的正相关可能是分娩后增加肝脏铁释放和红细胞生成所必需的。
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