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多能干细胞中的 SIRT2 和糖酵解酶乙酰化。

SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells.

机构信息

Genome Institute of Singapore, 60 Biopolis Street, 138675 Singapore.

出版信息

Nat Cell Biol. 2017 Apr 27;19(5):412-414. doi: 10.1038/ncb3522.

DOI:10.1038/ncb3522
PMID:28446816
Abstract

The metabolic transition from mitochondrial oxidative phosphorylation (OXPHOS) to glycolysis is critical for somatic reprogramming of induced pluripotent stem cells (iPSCs). SIRT2 has now been established as a previously unknown regulator of this metabolic transition during somatic reprogramming by controlling the acetylation status of glycolytic enzymes.

摘要

线粒体氧化磷酸化 (OXPHOS) 到糖酵解的代谢转变对于诱导多能干细胞 (iPSC) 的体细胞重编程至关重要。SIRT2 现已被确定为体细胞重编程过程中这一代谢转变的一个先前未知的调节因子，通过控制糖酵解酶的乙酰化状态来实现。

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