Shyh-Chang Ng, Ng Huck-Hui
Genome Institute of Singapore, Singapore 138675.
Genes Dev. 2017 Feb 15;31(4):336-346. doi: 10.1101/gad.293167.116. Epub 2017 Mar 17.
Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates. The metabolic programming of stem cells represents a fine balance between the intrinsic needs of a cellular state and the constraints imposed by extrinsic conditions. A more complete understanding of these needs and constraints will afford us greater mastery over our control of stem cell fates.
代谢组学的进展加深了我们对特定代谢模式在干细胞命运编程中所起作用的理解。在此，我们回顾了近期关于干细胞代谢的代谢组学研究，这些研究揭示了代谢途径如何将外在环境或其生态位的变化传递给干细胞命运编程。干细胞的代谢编程代表了细胞状态的内在需求与外在条件所施加的限制之间的精细平衡。对这些需求和限制有更全面的理解将使我们在控制干细胞命运方面拥有更大的掌控力。
