Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, Massachussetts, USA.
Nat Cell Biol. 2017 Apr 27;19(5):414-415. doi: 10.1038/ncb3521.
Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.
功能失调的细胞通过细胞挤出过程从上皮单层中被清除，以维持组织内稳态。现在已经证明，正常上皮细胞通过 PDK4 介导的 PDH 和线粒体代谢抑制诱导致癌基因表达细胞的代谢变化，从而诱导致癌基因转化细胞的挤出。
