Naderi Mohammad, Hashemi Mohammad, Moradi Nazanin
Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mol Biol Res Commun. 2017 Mar;6(1):23-26.
This study was designed to find out the impact of the variable number of tandem repeats (VNTR) of the tumor necrosis factor receptor 2 () on pulmonary tuberculosis (PTB) risk in an Iranian population. This case-control study was done on 159 PTB patients and 158 healthy subjects. Bi-allelic VNTR was genotyped by polymerase chain reaction. Logistic regression analysis revealed no significant association between VNTR and PTB risk (P>0.05). Our findings proposed that VNTR polymorphism is unlikely to confer susceptibility to PTB.
本研究旨在探讨肿瘤坏死因子受体2（）串联重复序列可变数目（VNTR）对伊朗人群肺结核（PTB）发病风险的影响。本病例对照研究共纳入159例PTB患者和158例健康受试者。采用聚合酶链反应对双等位基因VNTR进行基因分型。逻辑回归分析显示VNTR与PTB风险之间无显著关联（P>0.05）。我们的研究结果表明，VNTR多态性不太可能导致PTB易感性。
