I/D和A - 181G变异与终末期肾病风险
I/D and A-181G variants and the risk of end stage renal disease.
作者信息
Rahimi Zohreh, Abdi Hamed, Tanhapoor Maryam, Rahimi Ziba, Vaisi-Raygani Asad, Nomani Hamid
机构信息
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Mol Biol Res Commun. 2017 Mar;6(1):41-44.
The variants of angiotensin converting enzyme () and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the insertion/deletion (I/D) and A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency of I/D variants was not significantly different between ESRD patients and controls. However, the presence of D allele increased the risk of hypertension in ESRD patients by 2.14-fold (P=0.036). The -181 AG genotype increased the risk of ESRD by 2.04 times (P=0.026). The present study indicated the absence of an association between the I/D polymorphism with the risk of ESRD. However, the ACE D allele increased the risk of hypertension in ESRD patients. Also, the present study suggests a role for AG genotype in the pathogenesis of ESRD.
血管紧张素转换酶（ACE）和基质金属蛋白酶（MMPs）基因的变异可能参与终末期肾病（ESRD）和高血压的发病机制。我们研究了来自伊朗西部库尔德族背景的99例无关ESRD患者和117例无肾脏并发症个体中的ACE插入/缺失（I/D）和ACE A-181G变异。ESRD患者和对照组之间ACE I/D变异的频率无显著差异。然而，ACE D等位基因的存在使ESRD患者患高血压的风险增加了2.14倍（P = 0.036）。ACE -181 AG基因型使ESRD风险增加了2.04倍（P = 0.026）。本研究表明ACE I/D多态性与ESRD风险之间不存在关联。然而，ACE D等位基因增加了ESRD患者患高血压的风险。此外，本研究提示AG基因型在ESRD发病机制中起作用。
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