• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population.血管紧张素转换酶插入/缺失多态性与慢性阻塞性肺疾病：一项针对印度北部人群的病例对照研究。
Mol Biol Res Commun. 2019 Dec;8(4):167-170. doi: 10.22099/mbrc.2019.34904.1438.
2
The link between angiotensin-converting enzyme genotype and pulmonary artery pressure in patients with COPD.慢性阻塞性肺疾病患者血管紧张素转换酶基因型与肺动脉压之间的联系。
Wien Klin Wochenschr. 2005 Mar;117(5-6):210-4. doi: 10.1007/s00508-005-0333-z.
3
The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease.血管紧张素转换酶基因插入/缺失多态性与慢性阻塞性肺疾病
Genet Mol Res. 2013 Apr 25;12(2):1392-8. doi: 10.4238/2013.April.25.10.
4
Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease.血管紧张素转换酶基因插入/缺失多态性对慢性阻塞性肺疾病发生风险及病程的影响
Arch Med Sci. 2016 Apr 1;12(2):279-87. doi: 10.5114/aoms.2015.50757. Epub 2016 Apr 12.
5
The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population.血管紧张素I转换酶基因的插入缺失（I28005D）多态性是亚洲印度人群骨关节炎的一个风险因素。
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1281-7. doi: 10.1177/1470320314547403. Epub 2014 Sep 1.
6
Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to preterm birth: A case-control study and meta-analysis.血管紧张素转换酶基因插入/缺失多态性与早产易感性的关联：一项病例对照研究与荟萃分析
Eur J Obstet Gynecol Reprod Biol. 2018 Dec;231:122-128. doi: 10.1016/j.ejogrb.2018.09.019. Epub 2018 Sep 11.
7
Association of angiotensin converting enzyme gene insertion/deletion polymorphism with essential hypertension in south Indian population.血管紧张素转换酶基因插入/缺失多态性与印度南部人群原发性高血压的关联。
Genes Dis. 2016 Mar 25;3(2):159-163. doi: 10.1016/j.gendis.2016.03.001. eCollection 2016 Jun.
8
Angiotensin-converting enzyme gene I/D polymorphism increases the susceptibility to hypertension and additive diseases: A study on North Indian patients.血管紧张素转换酶基因I/D多态性增加高血压及附加疾病易感性：一项针对北印度患者的研究
Clin Exp Hypertens. 2016;38(3):305-11. doi: 10.3109/10641963.2015.1107085. Epub 2016 Mar 30.
9
Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism is not a risk factor for hypertension in SLE nephritis.血管紧张素转换酶（ACE）基因插入/缺失多态性不是系统性红斑狼疮肾炎患者发生高血压的危险因素。
Clin Rheumatol. 2015 Sep;34(9):1545-9. doi: 10.1007/s10067-015-2954-6. Epub 2015 May 10.
10
Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease.血管紧张素转换酶基因多态性、吸烟与慢性阻塞性肺疾病
Int J Chron Obstruct Pulmon Dis. 2007;2(3):329-34.

引用本文的文献

1
Increased Frequency of Angiotensin-Converting Enzyme D Allele in Asian Patients With Chronic Obstructive Pulmonary Disease: An Updated Meta-Analysis.亚洲慢性阻塞性肺疾病患者血管紧张素转化酶 D 等位基因频率增加：更新的荟萃分析。
Clin Respir J. 2024 Aug;18(8):e70002. doi: 10.1111/crj.70002.
2
Association between gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population.印度北部人群中基因多态性与慢性阻塞性肺疾病风险之间的关联。
Mol Biol Res Commun. 2020 Jun;9(2):41-43. doi: 10.22099/mbrc.2019.34594.1431.

本文引用的文献

1
gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis.基因多态性与慢性阻塞性肺疾病及慢性阻塞性肺疾病合并肺动脉高压相关：一项荟萃分析。
Int J Chron Obstruct Pulmon Dis. 2018 Aug 13;13:2435-2446. doi: 10.2147/COPD.S168772. eCollection 2018.
2
Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: A Promising Medication for Chronic Obstructive Pulmonary Disease?血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂：慢性阻塞性肺疾病的一种有前景的药物？
COPD. 2018 Apr;15(2):148-156. doi: 10.1080/15412555.2018.1432034. Epub 2018 Mar 9.
3
I/D and A-181G variants and the risk of end stage renal disease.I/D和A - 181G变异与终末期肾病风险
Mol Biol Res Commun. 2017 Mar;6(1):41-44.
4
Effect of angiotensin 2 receptor blockers on chronic obstructive lung disease mortality: A retrospective cohort study.血管紧张素2受体阻滞剂对慢性阻塞性肺疾病死亡率的影响：一项回顾性队列研究。
Pulm Pharmacol Ther. 2017 Jun;44:78-82. doi: 10.1016/j.pupt.2017.03.007. Epub 2017 Mar 14.
5
Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis.血管紧张素转换酶基因多态性与慢性阻塞性肺疾病风险：一项更新的荟萃分析。
Biomed Res Int. 2016;2016:7636123. doi: 10.1155/2016/7636123. Epub 2016 Oct 18.
6
Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease.血管紧张素转换酶基因插入/缺失多态性对慢性阻塞性肺疾病发生风险及病程的影响
Arch Med Sci. 2016 Apr 1;12(2):279-87. doi: 10.5114/aoms.2015.50757. Epub 2016 Apr 12.
7
Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population.GSTM1T1 基因与北印度人群 COPD 和前列腺癌的关联。
Mol Biol Rep. 2011 Mar;38(3):1733-9. doi: 10.1007/s11033-010-0287-8. Epub 2010 Sep 15.
8
Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease.血管紧张素转换酶基因多态性、吸烟与慢性阻塞性肺疾病
Int J Chron Obstruct Pulmon Dis. 2007;2(3):329-34.
9
A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.血管紧张素转换酶基因多态性与缺血性心脏病风险的前瞻性评估。
N Engl J Med. 1995 Mar 16;332(11):706-11. doi: 10.1056/NEJM199503163321103.
10
Angiotensin-converting enzyme and its clinical significance--a review.血管紧张素转换酶及其临床意义——综述
J Clin Pathol. 1983 Aug;36(8):938-47. doi: 10.1136/jcp.36.8.938.

血管紧张素转换酶插入/缺失多态性与慢性阻塞性肺疾病：一项针对印度北部人群的病例对照研究。

Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population.

作者信息

Kirtipal Nikhil, Thakur Hitender, Sobti Ranbir Chander

机构信息

Department of Biotechnology, Panjab University, Chandigarh-160014, India.

Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India.

出版信息

Mol Biol Res Commun. 2019 Dec;8(4):167-170. doi: 10.22099/mbrc.2019.34904.1438.

DOI:10.22099/mbrc.2019.34904.1438
PMID:32042834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6995333/
Abstract

This research aimed to explore the (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).

摘要

本研究旨在探讨（插入/缺失）基因关联作为印度北部人群慢性阻塞性肺疾病（COPD）发病的关键因素。选取了200例临床诊断为COPD的患者，并与200名健康个体进行对照。采用聚合酶链反应技术评估（插入/缺失）的基因变异。吸烟者患COPD的风险更高（OR=1.67，95%CI=1.12-2.48，P=0.012）。目前的结果显示DD基因型与COPD风险之间存在正相关（OR=2.14，95%CI=1.22-3.78，P=0.006）。在吸烟者中，DD基因型与COPD风险增加之间存在统计学显著关联（OR=3.10，95%CI=1.50-6.47，P=0.001）。