血管紧张素转换酶插入/缺失多态性与慢性阻塞性肺疾病：一项针对印度北部人群的病例对照研究。
Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population.
作者信息
Kirtipal Nikhil, Thakur Hitender, Sobti Ranbir Chander
机构信息
Department of Biotechnology, Panjab University, Chandigarh-160014, India.
Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India.
出版信息
Mol Biol Res Commun. 2019 Dec;8(4):167-170. doi: 10.22099/mbrc.2019.34904.1438.
Abstract
This research aimed to explore the (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).
摘要
本研究旨在探讨（插入/缺失）基因关联作为印度北部人群慢性阻塞性肺疾病（COPD）发病的关键因素。选取了200例临床诊断为COPD的患者，并与200名健康个体进行对照。采用聚合酶链反应技术评估（插入/缺失）的基因变异。吸烟者患COPD的风险更高（OR=1.67，95%CI=1.12-2.48，P=0.012）。目前的结果显示DD基因型与COPD风险之间存在正相关（OR=2.14，95%CI=1.22-3.78，P=0.006）。在吸烟者中，DD基因型与COPD风险增加之间存在统计学显著关联（OR=3.10，95%CI=1.50-6.47，P=0.001）。
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