人嗜T淋巴细胞病毒1型（HTLV-1）的p40tax对SV40转录增强子的细胞系特异性激活。
Cell-line specific activation of SV40 transcriptional enhancer by p40tax of HTLV-1.
作者信息
Fujisawa J, Seiki M, Toita M, Miyatake S, Arai K, Yoshida M
机构信息
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
出版信息
Jpn J Cancer Res. 1988 Jul;79(7):800-4. doi: 10.1111/j.1349-7006.1988.tb00038.x.
Abstract
A transcriptional trans-activator p40tax of HTLV-1 was reported to activate HTLV-1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40tax. These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p40tax. Since p40tax-mediated activation of the LTR is not cell line-specific, the activation of enhancers by p40tax depends on the combination of enhancer and cell type used for the test. Thus, apparent activation by p40tax depends on variable cellular components involved in transcriptional regulation.
摘要
据报道，人类嗜T细胞病毒1型（HTLV-1）的转录反式激活因子p40tax可激活HTLV-1增强子，但不能激活SV40或劳氏肉瘤病毒增强子。然而，在某些细胞系中，我们发现SV40增强子可被p40tax激活。这些细胞系大多为T细胞，在没有p40tax的情况下，SV40增强子仅表现出低活性。由于p40tax介导的长末端重复序列（LTR）激活并非细胞系特异性的，p40tax对增强子的激活取决于用于测试的增强子和细胞类型的组合。因此，p40tax的明显激活取决于转录调控中涉及的可变细胞成分。
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