皮肤源性1型人乳头瘤病毒的E6蛋白抑制p53介导的反式激活作用，而5型、8型或47型则无此作用。
Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, or 47, human papillomavirus of cutaneous origin.
作者信息
Kiyono T, Hiraiwa A, Ishii S, Takahashi T, Ishibashi M
机构信息
Laboratory of Viral Oncology, Aichi Cancer Center, Nagoya, Japan.
出版信息
J Virol. 1994 Jul;68(7):4656-61. doi: 10.1128/JVI.68.7.4656-4661.1994.
Abstract
Transient transfection experiments indicated (i) that E6 protein of non-cancer-associated cutaneous human papillomavirus type 1 (HPV-1) can inhibit p53-mediated transcriptional transactivation in both p53-deficient human cells (H358) and normal rat cells (3Y1), but those of cancer-associated cutaneous HPV-5, -8, and -47 cannot do so in either H358 or 3Y1 cells, and (ii) that E6 proteins of HPV-16 and -18 can inhibit the p53 function in H358 cells but not in 3Y1 cells.
摘要
瞬时转染实验表明
（i）非癌相关的皮肤人类乳头瘤病毒1型（HPV-1）的E6蛋白，在p53缺陷的人类细胞（H358）和正常大鼠细胞（3Y1）中均能抑制p53介导的转录反式激活，但癌相关的皮肤HPV-5、-8和-47的E6蛋白在H358或3Y1细胞中均无此作用；（ii）HPV-16和-18的E6蛋白能在H358细胞中抑制p53功能，但在3Y1细胞中则不能。
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